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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

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Vitamin B Complex injections deliver a concentrated blend of essential B vitamins directly into the bloodstream, allowing for efficient absorption and faster utilization by the body

There are oral supplements available, but the hydroxcobalamin injection remains in the body ugh longer

In fact, treatment might be more effective if it includes supplementation